Economically, Lyon is a major centre for banking, as well as for the chemical, pharmaceutical, and biotech industries. The city contains a significant software industry with a particular focus on video games, and in recent years has fostered a growing local start-up sector. Lyon hosts the international headquarters of Interpol, the International Agency for Research on Cancer and Euronews. According to the Globalization and World Rankings Research Institute, Lyon is considered a Beta city, as of 2018. It ranked second in France and 40th globally in Mercer's 2019 liveability rankings. The city is home to the headquarters of many large companies such as Groupe SEB, Sanofi Pasteur, Renault Trucks, Norbert Dentressangle, LCL S.A., Descours & Cabaud, Merial, Point S, BioMérieux, Iveco Bus, Compagnie Nationale du Rhône, GL Events, April Group, Boiron, Feu Vert, Panzani, Babolat, Euronews, Lyon Airports, LVL Medical, and inter-governmental agencies IARC, Interpol. The specialisation of some sectors of activities has led to the creation of many main business centres: La Part-Dieu, located in the 3rd arrondissement is the second biggest business quarter after La Défense in Paris with over 1,600,000 m2 (17,222,256.67 sq ft) of office space and services and more than 55,000 jobs. Cité Internationale, created by the architect Renzo Piano is located in the border of the Parc de la Tête d'Or in the 6th arrondissement. The district of Confluence, in the south of the historic centre, is a new pole of economical and cultural development. In 2017, the Lyon region ranked as the leading industrial region in France with a total of 770,000 companies, 500,000 jobs in industry, and 14 competitive clusters encompassing various sectors such as Life Sciences, Cleantech and Digital technologies.